In a 3-hour game, the San Francisco 49ers played about 10 minutes of good football as the Houston Texans dominated in every aspect of a 26-15 game that was nowhere near that close.

The 49ers offense sabotaged the defense and the defense failed to set up the offense in one-sided loss to Texans.

Kyle Shanahan provided a series of injury updates after San Francisco fell to the Houston Texans on Sunday afternoon.

In a virtual must-win situation, the Texans' offense piled up the yards against the 49ers while the defense held firm for much of the game.

Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 2.5-point favorites, according to the latest 49ers vs. Texans odds. The over/under for total points scored is 42. The Texans are -151 money line favorites (risk $151 to win $100),

For the first time in nearly a year, the 49ers defense has notched an interception, ending an NFL record-long drought.

Highlights from the Week 8 matchup between the San Francisco 49ers and the Houston Texans during the 2025 NFL season.

The San Francisco 49ers got Alfred Collins back late in the second quarter against the Texans and almost immediately lost another defensive lineman.

The 49ers have played some bad football this season. But Sunday was something else entirely: The 49ers played so poorly against the Houston Texans that it makes you question if they can ever win again. Their performance in a 29-15 loss was, in a word, awful.