Drug development is a critical but notoriously resource- and time-consuming process. Traditional methods, such as high-throughput screening, rely on opportunistic ...

Building the complex 3D molecules needed for new medicines has always been a bit like assembling a puzzle with pieces that ...

A research team at the University of Münster led by chemist Prof Frank Glorius has synthesized so-called heteroatom-substituted cage-like 3D molecules. The innovative structures could help address key ...

A report in the journal Science from researchers in the UW–Madison Department of Chemistry represents a significant advance in making the types of molecules needed in drug development. Molecules with ...

Controlled generation of 3D molecules is highly valuable in drug design, enabling targeted modifications that preserve core structure and binding-relevant geometry while improving ...

The radical rebound. Computational visualization showing the carbon-centered radical (orange spin density) binding to the nickel-centered radical (blue spin density). Two perspectives are shown. LA ...