Maintaining a normal physiologic acid-base balance is essential for the functioning of every organ system in the body. The renal and pulmonary systems are the primary regulators of acid-base balance.

CHANGES in the pH of the blood in disease are very small – that is, with limits of 7.0 to 7.8 in extraordinary circumstances. Considering that large variations occur in the amounts of hydrogen ion ...

RECENTLY, we have encountered a series of patients with severe metabolic acidosis and serum pH values less than 7.0. Although such severe acidosis is widely regarded as leading rapidly to delirium and ...

Kidney function thresholds for hyperkalemia and metabolic acidosis are higher in patients with sickle cell disease (SCD), even falling within the normal range, a new study finds. Investigators studied ...

The most common causes of metabolic alkalosis are vomiting and diuretic use. Urine chloride levels are usually low among patients with vomiting and among those using diuretics, but may be high if the ...