Escherichia coli replicates its genome through a finely tuned ensemble of proteins that assemble at the replication fork to form the replisome. Central to this machinery are the DNA polymerase III ...

If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

Directed evolution has been instrumental in the development of biomolecules with unique and desired functions relative to their natural starting points. While many strategies work well for generating ...

We have gone further than ever before in creating life that is unlike anything that has evolved naturally. The genome of an Escherichia coli bacterium has been redesigned on a computer to use just 57 ...

The ability to precisely edit the genomes of bacteria has long been a goal of microbiologists. Such technology would enable scientists to make new inroads into studying disease, developing sustainable ...