Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. Many findings suggest that the disease has an autoimmune pathogenesis; the target of the immune ...

Antibodies against the inward rectifying potassium channel (KIR4.1) protein may be present in blood of healthy patients destined to develop multiple sclerosis (MS), results of a small study suggest.

Enhanced bursting activity of neurons in the lateral habenula (LHb) is essential in driving depression-like behaviours, but the cause of this increase has been unknown. Here, using a high-throughput ...

In a large, blinded replication study, we tested serum samples obtained from 141 patients with multiple sclerosis (including 82 with CIS) and 131 controls (including 48 with other noninflammatory ...

Although multiple sclerosis is widely accepted as having an autoimmune pathogenesis, the target of the immune response is still unknown. To identify antibodies capable of binding to brain tissue, ...

Diagnosing multiple sclerosis is a challenge even for experienced neurologists. This autoimmune disease has many symptoms and rarely presents a uniform clinical picture. New findings on the immune ...

Humoral autoimmune responses are implicated in the pathogenesis of multiple sclerosis (MS), and a study from 2012 suggested that the glial inwardly rectifying potassium channel KIR4.1 might be a ...

For the first time, scientists in Germany's multiple sclerosis competence network have been able to identify an antibody that bonds with the potassium channel KIR4.1. "We found this autoantibody in ...