Discover the latest articles and news in related subjects. Prior to EPR analyses, we determined whether spin-labeled t-SNARE components were capable of assembling into complexes. Complex formation was ...

Discover the latest articles and news in related subjects. Our results indicate that in nerve terminals, SNAP-25 exists in equilibrium between ubiquitin-dependent degradation and SNARE-complex ...

In 2013, James E. Rothman, Randy W. Schekman, and Thomas C. Südhof won the Nobel Prize in Physiology or Medicine for their discoveries of molecular machineries for vesicle trafficking, a major ...

To release neurotransmitters, nerve terminals must repeatedly break down and rebuild specialized protein complexes, and the fidelity of this process may rely on α-synuclein, a protein that misfolds in ...

SNARE proteins are a large protein superfamily consisting of more than 60 members in yeast and mammals. The primary role of these proteins is to mediate fusion of vesicles with their target membrane ...

A team of researchers from the College of Natural Sciences is the first to show how proteins called “chaperones” are vital in ensuring that neurons can transmit signals to one another. When this ...

Every time a hormone is released from a cell, every time a neurotransmitter leaps across a synapse to relay a message from one neuron to another, the cell must undergo exocytosis. This is the process ...

Over 30 years ago, we observed what we interpreted to be vesicular transport in crude extracts of tissue culture cells. In subsequent years we found that we had reconstituted vesicle trafficking in ...

For this article, Eugene Russo interviewed Axel T. Brunger, a Howard Hughes Medical Institute investigator and professor of molecular and cellular physiology at Stanford University. Data from the Web ...

KAIST researchers discovered that NSF unravels a single SNARE complex using one round ATP turnover by tearing the complex with a single burst, contradicting a previous theory that it unwinds in a ...