To their surprise, both groups found that the 'transdifferentiated' cells carried markers for both the ES cells and the adult cells. In addition, the cells were tetraploid. It therefore seemed that, ...

Cellular reprogramming is like the fairytale of spinning straw into gold: you take an abundant, mundane cell type, dose it with a cocktail of chemicals, and voilà—now you have an unlimited supply of ...

How can a specialized cell change its identity? A research team investigated a 100% effective natural example of this phenomenon, which is called transdifferentiation. This process, by which some ...

We report on the case of a 41-year-old man with a 2.1-cm primary malignant melanoma of the skin, located on the crown of the head. The tumor was stage pT4 (with invasion of contiguous structures), ...

Cell differentiation is a widely studied phenomenon forming the basis of all developmental processes including fetal growth and bone fracture healing. A series of recent studies indicates the emerging ...

Tsukuba, Japan—Vascular diseases such as atherosclerosis, pulmonary hypertension, and cardiac fibrosis are associated with a reorganization of the structure of blood vessels. Researchers led by the ...

Metaplasia is defined as the replacement of a fully differentiated cell type by another. There are several classical examples of metaplasia, one of the most frequent is called Barrett's esophagus.

Direct reprogramming or Transdifferentiation is a way of inducing changes in the cell type from one lineage into another lineage, bypassing pluripotency. This approach is an innovative choice to ...

Conrad Waddington famously visualized development as a landscape in which a young cell differentiates much as gravity acts on a ball, leading it down forked canals that represent alternate lineages. A ...

The ability to reliably convert the phenotype of one cell to another would be a game-changer for regenerative medicine. However, predicting the reprogramming factors necessary to induce cell ...

July 10, 2025 - A research team led by Professor Yiwei Li and Professor Bi-Feng Liu from the College of Life Science and Technology at Huazhong University of Science and Technology (HUST) published an ...