SINCE the introduction of nitrogen mustard, methyl-bis-β-(chloroethyl)-amine, or HN 2 (Fig. 1), as a therapeutic agent in human cancer a number of analogues and related alkylating agents have been ...

After encountering foreign antigen, B cells diversify their immunoglobulin genes by somatic hypermutation (SHM), gene conversion (GC) and class-switch recombination (CSR). SHM introduces mutations ...

Purpose: This phase III study compared the time to progression (TTP) of an oral regimen of dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine composed of a fixed combination of tegafur and ...

Uracil in DNA may result from incorporation of dUMP during replication and from spontaneous or enzymatic deamination of cytosine, resulting in U:A pairs or U:G mismatches, respectively. Uracil ...

Preoperative Therapy With Trastuzumab and Paclitaxel Followed by Sequential Adjuvant Doxorubicin/Cyclophosphamide for HER2 Overexpressing Stage II or III Breast ...

Back in 2010, Japan’s space agency JAXA completed one of the biggest milestones in the history of space exploration: It collected samples from an asteroid and brought them back to Earth. A decade ...

Samples from the asteroid Ryugu collected by the Hayabusa2 mission contain nitrogenous organic compounds, including the nucleobase uracil, which is a part of RNA. Researchers have analyzed samples of ...

Capecitabine (Xeloda) is a fluoropyrimidine carbamate precursor of 5-FU. It is given orally and is converted via several enzymatic steps to give intratumoural release of 5-FU. The enzyme involved in ...

Protein p56 encoded by the Bacillus subtilis phage φ29 inhibits host uracil-DNA glycosylase (UDG) activity. In previous studies, we suggested that this inhibition is likely a defense mechanism ...

From reproductive rights to climate change to Big Tech, The Independent is on the ground when the story is developing. Whether it's investigating the financials of Elon Musk's pro-Trump PAC or ...