After an injury, DNA not only changes its activity but also the way it is organized spatially within the cell nucleus. In ...

Cars patched up after a wreck may look fixed—but never run quite as before. The same may hold true for chromatin, according to a study published in Science on November 6. In response to double-strand ...

Every cell type in the human body carries the same approximately 3.2 billion base pairs of DNA, yet a liver cell behaves nothing like a neuron. The epigenome explains this difference: in each cell, ...

Every cell in your body faces the same engineering puzzle: how to cram roughly two meters of DNA into a nucleus just a few millionths of a meter wide, while still letting the right genes switch on at ...

Chromatin, the organised complex of DNA and histone proteins, undergoes rapid and regulated structural changes upon DNA damage to facilitate detection, signalling and repair. Following insult by ...

As humans get older, their brains undergo various changes that can affect mental functions. The cells known to be affected by ...

For the most part, every cell in the body has the same DNA, but each cell type, like brain or insulin-producing cells, uses it differently to perform specific functions. Epigenetic factors, which ...

AlphaGenome Atlas, Google DeepMind's new 1-petabyte genomics database, pre-computes predicted molecular effects for all 9 ...

Some of the signs of aging in human cells originate in the cell nucleus, because the packaged form of DNA changes with age. This has now been demonstrated by PSI researchers. It means that older cells ...