The Pittsburgh Pirates (20-36) and the Arizona Diamondbacks (27-28) wrap up a 3-game set Wednesday. First pitch from Chase Field in Phoenix is set for 3:40 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Pirates vs. Diamondbacks odds and make our expert MLB picks and predictions for the best bets.

Zac Gallen faces Paul Skenes, the 2024 National League Rookie of the Year Award with a 1.96 ERA in 23 starts, striking out 170 in 133 innings.

Paul Skenes pitched shutout ball into the seventh inning, Oneil Cruz hit a two-run homer and the Pittsburgh Pirates romped past the Arizona Diamondbacks 10-1 on Wednesday. The Pirates rallied from a 6-2 deficit with seven runs in the eighth inning to beat the Diamondbacks 9-6 on Tuesday night.