The Indianapolis Colts are No. 1 in the NFL in several key statistics. The Tennessee Titans are last in the league in many of those same areas.

Remember when the Tennessee Titans used to beat the Indianapolis Colts? Those days are long gone in a rivalry that has ceased to be competitive.

These three potential outcomes could sway the game in favor of the Indianapolis Colts vs. the Tennessee Titans.

Indianapolis is a 15-point favorite in the latest Titans vs. Colts odds from SportsLine consensus, while the over/under for total points scored is 47.5. Before making any Colts vs. Titans picks, make sure you check out the NFL picks from the SportsLine Projection Model.

IndyStar Colts Insider Joel A. Erickson is taking #AskJoel off X and onto IndyStar to talk about today's game. Ask him your questions here

Indianapolis Colts wide receiver Michael Pittman Jr. made an insane grab for a touchdown against the Tennessee Titans

Get ready for an exciting Colts vs. Titans game in Indianapolis! Join the fun in downtown Indianapolis with pregame activities and giveaways.