The San Francisco 49ers finished last in the NFC West in 2024 with a 6-11 record, going just 1-5 against division opponents.

Now, he's 29, which is old for a running back. Still, he's had a long offseason to recover and he says he's 100 percent ...

Guerendo was back on the depth chart but ended up as a starter. He had games with 99, 85 and 78 yards. While of the four ...

Second-year running back Isaac Guerendo shouldn't be feeling too complacent on the San Francisco 49ers' roster just yet. Despite turning things on late his rookie year in the wake of injuries to ...

Is Isaac Guerendo playing Week 15 vs. Rams? Guerendo was listed as a non-participant on Monday's estimated practice report before missing Tuesday's walk-through because of his foot sprain.

That was until Isaac Guerendo showed up. The rookie fourth-round pick in 2024 stepped into action on Sunday in Week 14, dominating the Bears to the tune of 128 total yards and two touchdowns.

49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being listed as questionable, per sources. Guerendo insists he “feels good ...

Isaac Guerendo hurt his foot in Week 14. And now, Patrick Taylor Jr. could be in line for a huge game in Week 15. Against Chicago, Taylor had seven carries for 25 yards and a score, and he was ...

DE Nick Bosa (hip, oblique), RB Isaac Guerendo (foot) and LB Dre Greenlaw (Achilles) are listed as questionable. — Adam Schefter (@AdamSchefter) December 11, 2024.

49ers' Isaac Guerendo: On field for OTAs. Guerendo (knee/ankle) was an active participant at voluntary OTAs, per the 49ers' official site.. Guerendo sustained MCL and ankle sprains in his left leg ...

And now the spotlight turns to Isaac Guerendo (12 percent rostered on CBS Sports). The rookie from Louisville, who is 6 feet, 221 pounds and runs a 4.33 40-yard dash, ...

SANTA CLARA, CALIFORNIA - NOVEMBER 17: Isaac Guerendo #31 of the San Francisco 49ers warms up before a game against the Seattle Seahawks at Levi's Stadium on November 17, 2024 in Santa Clara ...