Mechanosensitive ion channels are specialised membrane proteins that convert physical forces into electrical and biochemical signals, playing a pivotal role in numerous physiological processes.

Microglia, the immune cells that protect the brain, are thought to maintain a healthy brain environment by removing unwanted ...

Journavx revived an area of development long considered a graveyard. Can any other pain drugs keep investor excitement going?

A member of an important class of ion channel proteins can transiently rearrange itself into a larger structure with dramatically altered properties, according to a new study. The discovery is a ...

Researchers have identified two ion channel switches that regulate the release of dopamine in the brain, a first step that might one day lead to therapeutics for a wide range of diseases and disorders ...

Ion channels are attractive drug targets due to their importance in health and disease, but finding ways to target a specific ion channel selectively is a major challenge. Now, researchers have ...

When a scrappy team of scientists joined forces in the late 1990s, they sought to identify genetic mutations that could have an outsized impact on the treatment of human disease. At the time, that ...

All lifeforms need to continuously adapt to temperature changes to survive. Now, Weill Cornell Medicine investigators studying a bacterial protein have identified a new mechanism of sensing cold ...

Instrument Seeks to Advance Ligand-Gated Aspect of Critically Important Field The first decade of the 21st century has delivered an extraordinary range of new technologies with relevance to ...

Researchers have discovered how an ion channel in the brain's neurons has a kind of 'molecular memory', which contributes to the formation and preservation of lifelong memories. The researchers have ...

Researchers decipher the function of an ion channel involved in cellular degradation processes and create new possibilities for Parkinson’s therapies. Washbowls, bathtubs, and sinks are all fitted ...