From sponges to mammals, TGFβ signalling is a central regulator of body plan, cell fate and tissue homeostasis, with receptor architecture highly conserved across metazoans. Here we identify ...

Leucine-rich repeat (LRR) receptor kinases (RKs) and receptor proteins (RPs) are important classes of plant pattern recognition receptors (PRRs) activating pattern-triggered immunity. While both ...

In this study in silico docking models were employed to investigate the molecular interactions between the receptor-binding domain (RBD) of the SARS-CoV-2 spike glycoprotein, derived from the ...

A new study reveals how partial subunit binding locks the brain's most common kainate receptor into a permanently open state.

The researchers found that antibodies, including many used in clinical treatments, recognize nearly every exposed region of the spike protein's receptor-binding domain, a critical region of the virus.

Mentor(s): Michael Kennedy, Ph.D. Understanding binding of animal rotavirus strains offers insight into zoonotic potential The goal of this project is to determine if bat P[10] binds in an excited ...

A study from St. Jude Children's Research Hospital uncovered an alternative binding pocket within nuclear receptors, revealing a much-needed new therapy route for this important class of drug targets.