Transferrin-receptor shuttles distribute antibody cargo throughout the parenchyma, steering clear of ARIA-provoking vascular amyloid. Trontinemab is enrolling Phase 3 for early AD, announces plans for ...

In both amyotrophic lateral sclerosis and frontotemporal dementia, TDP-43, an RNA-binding protein that normally sits in the nucleus, aggregates in the cytoplasm. This same pathology also crops up in ...

As clinicians increasingly make use of amyloid PET, they need to know where to draw the line between amyloid-negative and -positive scans. In the July 13 JAMA, scientists led by Ganna Blazhenets and ...

Turns out, microglia need TDP-43 to properly shape the brain's white matter during development. In the July 8 Nature Neuroscience, scientists led by Rosa Paolicelli at the University of Lausanne, ...

Somewhere, a synapse fires. Sodium and calcium flood the dendrite and trigger transcription of genes necessary for learning and memory. Within minutes, the transport protein Arc reaches the dendrite ...

The center collects, processes, stores, and distributes samples, including longitudinal samples, from its research participants. Collections are taken from donors in their 40s to late 90s in a limited ...

Microdissection of more than 130 different brain nuclei is performed on frozen brains. These samples are approved for neurochemistry, neuroendocrine, molecular biology, proteomic and genomic studies.

This center only accepts brain tissue from patients evaluated, tested, and treated in its clinic for several years. The center keeps both healthy and diseased brains, but has more of the latter. It is ...

The brain bank houses one of the most extensive collections of human brain tissue in the southern hemisphere, comprising nine different neurological diseases such as Alzheimer’s, Huntington’s, ...

Not a brain bank per se, but a for-pay brain autopsy program. Some brains are kept after autopsy, and tissues from Alzheimer's, other neurological disorders and a few controls, are available to ...

Pre-Application (Letter of Intent) Submission Deadline: 5:00 p.m. Eastern Time (ET), October 23, 2026. Application Submission Deadline: 11:59 p.m. ET, November 6, 2026.

In the quest to understand how APOE4 heightens the risk of Alzheimer’s disease, scientists are drilling down to nuances such as how the variant acts in women versus men, and how it affects cell types.