An experimental medicine, 2-D08, boosts motor function in mice and primate models of multiple sclerosis (MS) by repairing the myelin sheath, the protective coating on nerve fibers that’s damaged in ...

Griffith Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia Griffith Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia School ...

Kir4.2 and Kir4.1 play a role in regulating membrane transport in the proximal tubule (PT) and in the distal-convoluted-tubule (DCT), respectively. AT1aR (angiotensin II type 1a receptor) determines ...

With advances in imaging techniques and basic science, clinicians can detect and take action against diabetic eye disease earlier than previously considered. Sixty years ago, William Beetham, MD, of ...

Diets with a high sodium-to-potassium ratio are linked to poor cardiovascular outcomes. Attention has mostly focused on high sodium, but low potassium is also a culprit in cardiovascular disease.

Satellite glia are the major glial cells in sympathetic ganglia, enveloping neuronal cell bodies. Despite this intimate association, the extent to which sympathetic functions are influenced by ...

In the last decades, increasing evidence has revealed that a large number of channel protein and ion pumps exhibit impaired expression in cancers. This dysregulation is responsible for high ...

The authors declare that all supporting data and detailed methods including animal preparation, electrophysiology, Western blot, and renal clearance method are available within the article (and its ...

In the interests of transparency, eLife includes the editorial decision letter and accompanying author responses. A lightly edited version of the letter sent to the authors after peer review is shown, ...

AT2R (AngII [angiotensin II] type 2 receptor) is expressed in the distal nephrons. The aim of the present study is to examine whether AT2R regulates NCC (Na-Cl cotransporter) and Kir4.1 of the distal ...