In both amyotrophic lateral sclerosis and frontotemporal dementia, TDP-43, an RNA-binding protein that normally sits in the nucleus, aggregates in the cytoplasm. This same pathology also crops up in ...

Somewhere, a synapse fires. Sodium and calcium flood the dendrite and trigger transcription of genes necessary for learning and memory. Within minutes, the transport protein Arc reaches the dendrite ...

As clinicians increasingly make use of amyloid PET, they need to know where to draw the line between amyloid-negative and -positive scans. In the July 13 JAMA, scientists led by Ganna Blazhenets and ...

Turns out, microglia need TDP-43 to properly shape the brain's white matter during development. In the July 8 Nature Neuroscience, scientists led by Rosa Paolicelli at the University of Lausanne, ...

Neurons need an ample flow of metabolic fuel to power protein production, especially during learning tasks. A paper published June 4 in Cell Metabolism online positions microglia at the tap, proposing ...

Scientists already suspect that somatic mutations—those that accrue in cells outside the germline over a person’s lifetime, seemingly at random—play a role in neurodegenerative diseases. Now, several ...

CAR-T cell therapy has practically become a household name, given its success in taking down blood cancers. The chimeric antigen receptors used in this type of cell therapy are designed to sic killer ...

During five 11-hour days in Copenhagen, Denmark, nearly 6,000 attendees soaked up talks and posters at the 20th International Conference on Alzheimer’s and Parkinson’s Diseases. From March 17-21, ...

The notion that lithium might treat Alzheimer’s was revived last year when scientists reported that the brains of people and mice with amyloid pathology are deficient in the metal ion, and that the ...

Amyloid plaques accumulate years before dementia, driven by release of the Aβ peptide from amyloid precursor protein (APP) in neurons. Now, new evidence points to synaptic vesicles as acidic hotspots ...

Post-marketing data chart immunotherapy performance in early-onset Alzheimer’s. The antibodies lowered amyloid and slowed functional decline. However, tangles continued to form. “These results offer ...

More antibodies take aim at seeded propagation. New data ties tangle location to deficits in specific cognitive domains. Three first-in-human studies for antibodies targeting different parts of tau ...