Optimizing sample preparation is critical for generating high-quality, reproducible analytical data, particularly when working with complex matrices. Yet, it often demands significant time and effort.

Closing out the Peer Exchange, Bryan Vining poses a final question: what would the panel want a non-analytical scientist to know before requesting a per- and polyfluoroalkyl substances (PFAS) analysis ...

Cardinal Health discusses with LCGC International how switching from reversed-phase to hydrophilic interaction liquid chromatography (HILIC) can unmask a hidden excipient artifact mistaken for a true ...

He describes how labs often receive samples with vague instructions to simply "find out what PFAS are in it," when what's ...

Bryan Vining introduces one of the most persistent problems in per- and polyfluoroalkyl substances (PFAS) work: background contamination. Because PFAS compounds are so ubiquitous, he notes, measuring ...

Bryan Vining notes that early PFAS concern centered on eight-carbon compounds like perfluorooctanoic acid (PFOA) and ...

Technique selection hinges on volatility/polarity; LC‑HRMS typically initiates characterization for nonvolatile/semi-volatile features, while GC‑MS can resolve ...

LC-MS/MS identified chlortetracycline in 1/29 and doxycycline in 4/29 chicken-based cat kibbles, indicating sporadic antibiotic carryover into finished commercial diets. PFAS were detected in 7/29 ...

Shimadzu expanded its eTOC portfolio with the TOC-1000e S to continuously quantify trace organic contamination in ultrapure ...

Ambient ionization via rapid evaporative ionization MS provided near-real-time lipid fingerprints, complementing hyphenated ...

This article outlines current and emerging trends in the analysis of GLP-1 receptor agonists, with a focus on liquid chromatography (LC), mass spectrometry (MS), and regulatory expectations. GLP-1 ...

The manufacturing of “true” biopharmaceuticals such as antibody drugs can be challenging, and so-called middle-molecule drugs, including peptide therapeutics, have gained significant attention.