Optimizing sample preparation is critical for generating high-quality, reproducible analytical data, particularly when working with complex matrices. Yet, it often demands significant time and effort.

Bryan Vining notes that early PFAS concern centered on eight-carbon compounds like perfluorooctanoic acid (PFOA) and ...

He describes how labs often receive samples with vague instructions to simply "find out what PFAS are in it," when what's ...

LC-MS/MS identified chlortetracycline in 1/29 and doxycycline in 4/29 chicken-based cat kibbles, indicating sporadic antibiotic carryover into finished commercial diets. PFAS were detected in 7/29 ...

Cardinal Health discusses with LCGC International how switching from reversed-phase to hydrophilic interaction liquid chromatography (HILIC) can unmask a hidden excipient artifact mistaken for a true ...

Jie Du of Cardinal Health discusses with LCGC International how switching from reversed-phase to hydrophilic interaction liquid chromatography (HILIC) can unmask a hidden excipient artifact mistaken ...

Closing out the Peer Exchange, Bryan Vining poses a final question: what would the panel want a non-analytical scientist to know before requesting a per- and polyfluoroalkyl substances (PFAS) analysis ...

The workshop will cover multidimensional gas and liquid chromatography trends, featuring keynote speakers from academia and industry. Participants can engage in guided discussions, poster sessions, ...

Bryan Vining introduces one of the most persistent problems in per- and polyfluoroalkyl substances (PFAS) work: background contamination. Because PFAS compounds are so ubiquitous, he notes, measuring ...

Technique selection hinges on volatility/polarity; LC‑HRMS typically initiates characterization for nonvolatile/semi-volatile features, while GC‑MS can resolve ...

Matrix effects in LC can enhance or suppress detector responses, impacting quantitation accuracy. Understanding these effects is crucial for method development and troubleshooting. Mitigation ...

Webcasts: ChromAcademy | LCGC International provides separation science insights, including liquid chromatography (HPLC), gas chromatography (GC), and mass spectrometry (MS).