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A new paper found the estradiol level tied to protecting your heart and bones, and the guidelines haven't caught up. Piette and Simon (Gynecological Endocrinology, 2026) lined up serum estradiol from transdermal trials against KEEPS and ELITE. The protective range landed near 60 pg/mL. The twist: the most popular patch dose already delivers about 57. Women and their prescribers arrived there on their own. The honest catch: hormone therapy is guideline-approved for bone (osteoporosis) prevention,
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